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目的研究低分子量肝素(LMWH)防治血液透析(HD)中急、慢性肾功能衰竭(肾衰)患者的出血倾向。方法对24例患者选用LMWH(速避凝)做抗凝剂。在每次HD前单剂量从动脉注入速避凝0.4ml,共HD95例次,均顺利完成透析全过程。结果无透析器及管道凝血,未发现原有出血加重或发生新的出血灶。穿刺压迫止血时间8.0±1.0分,明显短于普通肝素组的12.1±1.1分。结论LMWH能有效阻止血液在体外循环中凝固,且不发生出血并发症。
Objective To investigate the bleeding tendency of low molecular weight heparin (LMWH) in the prevention and treatment of acute and chronic renal failure (renal failure) in hemodialysis (HD). Methods Twenty-four patients were selected as anticoagulant with LMWH (fast evacuation). In each HD before a single dose from the arterial infusion rate of condensate 0.4ml, a total of HD95 cases, were the successful completion of the entire dialysis process. Results No dialyzer and coagulation of blood vessels, bleeding was not found or the occurrence of new hemorrhagic foci. Puncture and compression hemostasis time 8.0 ± 1.0 points, significantly shorter than the unfractionated heparin group 12.1 ± 1.1 points. Conclusion LMWH can effectively prevent the blood coagulation during cardiopulmonary bypass without bleeding complications.