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目的观察全反式维甲酸(ATRA)、三氧化二砷(As2O3)及联合高三尖杉酯碱(HHT)治疗初发急性早幼粒细胞白血病(APL)的疗效和不良反应。方法As2O3、ATRA联合高三尖杉酯碱治疗初治APL患者31例,As2O30.1%注射液10 ml加入5%葡萄糖溶液500 ml静脉滴注,持续4~6 h,1次/d;ATRA25 mg/(m.d),分3次口服,观察CR率,获得CR所需时间、不良反应。结果30例患者获得完全缓解(CR),CR率96.8%,获得缓解时间(28.3±4.2)d,没有发现明显的不良反应。结论As2O3、AT-RA及联合高三尖杉酯碱治疗初发APL患者疗效好,能缩短CR的时间,减轻高白细胞反应,长期CR时间需要进一步观察。
Objective To observe the efficacy and adverse reactions of all-trans retinoic acid (ATRA), arsenic trioxide (As2O3) and combined Homoharringtonine (HHT) in the treatment of acute promyelocytic leukemia (APL). Methods 31 cases of newly diagnosed APL patients were treated with As2O3 and ATRA combined with homoharringtonine, 10 ml of As2O30.1% injection and 500 ml of 5% dextrose solution were intravenously instilled for 4 ~ 6 h and once daily for 24 h. ATRA 25 mg / (md), 3 times orally, observe the CR rate, the time required to obtain CR, adverse reactions. Results 30 patients achieved complete remission (CR), CR rate was 96.8%, and the remission time was (28.3 ± 4.2) d. No obvious adverse reactions were found. Conclusion As2O3, AT-RA combined with homoharringtonine in the treatment of APL patients have good curative effect, which can shorten the time of CR and relieve the response of high white blood cells. The long-term CR time needs further observation.