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40只大鼠随机分为3个实验组和1个对照组,实验组灌服新鲜草鱼胆汁。结果表明:实验鼠肾小管及肾小球病变明显;肾小管上皮细胞碱性磷酸酶(AKP)、酸性磷酸酶(ACP)、琥珀酸脱氢酶(SDH)、细胞色素氧化酶(CCO)活性降低;肾小球和肾小管基底膜LN增多;血清BUN、SGPT升高。病变程度显示剂量一效应关系。进一步表明急性草鱼胆汁中毒病程迁延时,主要靶组织是肾小管和肾小球,其死因是急性肾功能衰竭。
Forty rats were randomly divided into three experimental groups and one control group. The experimental group was fed with fresh grass carp bile. The results showed that: renal tubular and glomerular lesions were evident in experimental mice; renal tubular epithelial cells alkaline phosphatase (AKP), acid phosphatase (ACP), succinate dehydrogenase (SDH), cytochrome oxidase (CCO) activity Lowered; glomerular and tubular basement membrane LN increased; serum BUN, SGPT increased. The extent of the lesion shows a dose-effect relationship. It further shows that the disease course of acute grass carp bile poisoning is delayed. The main target tissues are renal tubules and glomeruli. The cause of death is acute renal failure.