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以缓慢混合钙和磷前驱物溶液的化学沉淀法制备类球形羟基磷灰石(HAp)颗粒,通过正交实验法以高的吸附药物分子(亚甲基蓝)数量及低的标准偏差为依据确定溶胶-凝胶工艺的最优条件,在疏硅醇性的HAp颗粒表面均匀沉积介孔二氧化硅(mSiO2)壳层,制备得到具有核壳结构的HAp/mSiO2颗粒,在0.10g/L的亚甲基蓝溶液中吸附量高达79.26mg/g,标准偏差为4.42。亚甲基蓝分子在颗粒上的吸附行为属于第II型吸附等温线,即分子以单体和二聚体的形式吸附在孔内。在磷缓冲液(pH=7.2~7.4)和Lysosome-like缓冲液(pH=4.7)中药物分子自载药颗粒中的释放行为有明显的pH值敏感性能,这与溶液离子对载药颗粒结构和药物分子与载体间的作用机制的影响有关。
Spherical hydroxyapatite (HAp) particles were prepared by chemical precipitation method with slow mixing of calcium and phosphorus precursors solution. The orthogonal experiment was used to determine the number of highly adsorbed drug molecules (methylene blue) and the low standard deviation (RSD) Gel process, the mesoporous silica (mSiO2) shell was uniformly deposited on the surface of the sparse silanol group HAp particles to prepare HAp / mSiO2 particles with a core-shell structure. In a solution of 0.10 g / L methylene blue solution The adsorption capacity of up to 79.26mg / g, the standard deviation of 4.42. The adsorption behavior of methylene blue molecules on the particles belongs to the type II adsorption isotherm, that is, the molecules are adsorbed in the pores in the form of monomers and dimers. The release behavior of drug molecules from drug-loaded particles in pH buffer (pH 7.2 ~ 7.4) and Lysosome-like buffer (pH = 4.7) showed obvious pH sensitivity, which was in agreement with the effect of solution ion on drug particle structure And drug molecules and the role of the mechanism of interaction between.