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目的探讨克隆特合漱液对口腔细菌的抑菌作用。方法将１２株厌氧菌、兼性厌氧菌及早株需氧菌分别接种在含不同浓度克隆特含漱液的培养基上，分别置入厌氧、需氧环境培养，观察抑菌效果，并与甲硝哇稀释液和克隆特含激液空白基质进行对比分析。结果克隆特含漱液稀释１０００倍时（含主药５．０旭／ｍｌ）对所有厌氧菌、兼性厌氧菌均有很强的抑菌作用；稀释１２０倍（４１．７＃ｇ／ｍｌ）时对甲、乙型溶血性链球菌有抑菌作用，对其它两种需氧菌无抑菌作用．结论克隆特含激液对口腔常见１６株细菌中的１４ｋ＄明显抑菌作用，可作为牙周组织疾病治疗或辅助治疗的药物之一。
Objective To investigate the antibacterial effect of clonidine gargle on oral bacteria. Methods 12 anaerobic bacteria, facultative anaerobic bacteria and early stage aerobic bacteria were inoculated on the medium containing gargle with different concentrations of cloning, respectively, and placed in anaerobic and aerobic culture respectively to observe the antibacterial effect, And comparative analysis of metronidazole and clonidine-containing blank matrix containing fluid contrast. Results Clonet gargle dilution of 1000 times (including the main drug 5.0 Xu / ml) for all anaerobic bacteria, facultative anaerobic bacteria have a strong antibacterial effect; diluted 120 times (41.7 # g / Ml) when A, B hemolytic streptococcus antibacterial effect, the other two kinds of aerobic bacteria without antibacterial effect. Conclusion Clontium-containing gels can significantly inhibit the 14 k $ of 16 common bacteria in the oral cavity, which can be used as a treatment or adjuvant therapy for periodontal tissue diseases.