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1975年7月到1980年4月湖北医学院第二附属医院收治了71例流行性出血热(EHF)病人。这些病人的临床过程与朝鲜出血热(KHF)、斯堪的纳维亚流行性肾病和苏联的伴肾综合征出血热相似。总的病死率为11.2％,从这些病人中的某些人及湖北医学院附一医院住院病人所取得的血清与朝鲜出血热相关抗原起反应,显示出极其高的抗体滴定。我们断言:中国中部的流行性出血热(EHF)与朝鲜出血热(KHF)是同一疾病。流行性出血热(EHF)是以发热、低血压、少尿和多尿等病期为特征的综合征在1950年～1952年的朝鲜战争中,这种疾病成为美国军队中发病率和病死率的主要原因。尽管对本病的认识和治疗方法有所改进,但当时对确定致病因子的大量研究未获成功。从那时起,关于北欧、朝鲜和苏联EHF的疫情均有所了解,但是涉及到中华人民共和国内EHF的疫情则几乎没有。最近,中华人民共和国和美利坚合众国政府之间的协议,使美国科学家到中国参加研究工作有了可能。1979年11月到1980年4月本文作者之一Myron.S.Cohen(MSC)在湖北医学院生活和工作,并得到了对流行性出血热患者进行观察和治疗的机会。同时部分患者血清由湖北医学院学者带至美国耶鲁大学医学院的病毒研究室、伟黑文医学中心和国立卫生研究院进行了病毒血清学研究,兹将有关研究的结果报告如下。
From July 1975 to April 1980, 71 cases of epidemic hemorrhagic fever (EHF) were admitted to the Second Affiliated Hospital of Hubei Medical College. The clinical course of these patients is similar to that of KHF, Scandinavian pandemic nephropathy and the Soviet Union with hemorrhagic fever with syndrome. The overall case fatality rate was 11.2%. Serum obtained from some of these patients and in-patients from the First Affiliated Hospital of Hubei Medical College reacted with the antigens associated with Korean hemorrhagic fever and showed extremely high antibody titrations. We assert that epidemic hemorrhagic fever (EHF) in central China is the same disease as North Korean hemorrhagic fever (KHF). Epidemic haemorrhagic fever (EHF) is a syndrome characterized by periods of fever, hypotension, oliguria and polyuria. During the Korean War from 1950 to 1952, the disease became the most common cause of morbidity and mortality in the U.S. military The main reason. Although the understanding and treatment of this disease has improved, but then a large number of studies to determine the causative agent was unsuccessful. Since then, there has been an overview of the outbreaks of EHF in Northern Europe, North Korea and the Soviet Union, but there are few outbreaks involving EHF in the People’s Republic of China. Recently, the agreement between the People’s Republic of China and the government of the United States of America has made it possible for U.S. scientists to participate in research work in China. November 1979 to April 1980 Myron S. Cohen (MSC), one of the authors of this article, lives and works in Hubei Medical College and has been given the opportunity to observe and treat patients with epidemic hemorrhagic fever. At the same time, some patients’ sera were taken from the Hubei Medical College to the Virology Laboratory of the Yale University School of Medicine, Weihaven Medical Center and the National Institutes of Health for serological research. The results of the research are reported as follows.