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为了探讨个旧炼厂烟尘与肺癌发生的关系,我们进行了有关烟尘诱癌的实验研究。首先,测定了烟尘中化学物质的相对含量,其主要成分为多种无机化学物质的混合物,未发现苯并芘,同时烟尘经 Ames 氏试验,诱突变结果阳性。继之进行四组动物实验,结果如下:1、Ⅰ组(烟尘组)第24周开始发现肺癌,发癌率34.78％。Ⅱ组(呋喃甲醛对照组)无一例呼吸道良、恶性肿瘤发生。Ⅲ组(烟尘加 DEN 组)17周开始发现肺癌,发癌率90.62％,Ⅳ组(DEN 组)25周发现肺癌,发癌率65.51％。由此可说明烟尘本身不仅有诱癌作用而且对 DEN 诱发金地鼠肺癌有明显的协同作用。2、三个实验组均以腺癌或以腺癌为主的复合癌较多。本文还对烟尘的诱癌作用和对 DEN 诱发肺癌的协同作用,烟尘中某些化学元素在肿瘤发生中的作用及有关预防等几方面问题作了探讨。
In order to investigate the relationship between smoke and dust in old refineries and the occurrence of lung cancer, we conducted an experimental study on smoke induced cancer. First, the relative amount of chemical substances in smoke was measured. The main component was a mixture of inorganic chemicals. No benzopyrene was found. The smoke and dust were positive by Ames test. Followed by four groups of animal experiments, the results are as follows: 1, group I (smoke group) began to find lung cancer in the 24th week, the rate of 34.78%. There was no case of respiratory and benign tumors in group II (furfural control group). In group III (smoke plus DEN group), lung cancer was found at 17 weeks, with a cancer rate of 90.62%. In group IV (DEN group), lung cancer was found at 25 weeks and the cancer rate was 65.51%. This shows that the smoke itself not only has a carcinogenic effect but also has a significant synergistic effect on DEN-induced gold hamster lung cancer. 2. In the three experimental groups, there were more adenocarcinomas or adenocarcinoma-based composite cancers. This paper also discusses the carcinogenesis of soot and its synergistic effects on DEN-induced lung cancer, the role of certain chemical elements in soot in tumorigenesis, and related prevention issues.