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Prevention and treatment of infection in burn patients involve a wide range of issues.This present article is to introduce only briefly clinical experience focusing on this problem.Among them,satisfactory timely prevention and treatment of burn shock is imperative because it exerts tremendous impact on homeostasis,including especially deterioration of immune functions.Early gastro-intestinal feeding is known to help restore gastro-intestinal circulation after shock,and it is an important avenue to give important nutritional elements like glutamine.It is also very important to excise devitalized tissue,followed by total coverage of all open wounds as early as possible,so that nidus of infection is removed.Rational ase of antibiotic,immunological modulation and other measured were also important contributory factors in successfully preventing and treating infection in patients with major burns.