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骨肿瘤中骨肉瘤（OS）和尤文肉瘤（ES）因具有较复杂的发生、发展、转移机制和不良预后而受到医学界的广泛关注。研究表明原癌基因的激活和抑癌基因的突变、凋亡信号缺失和乏氧诱导因子等均参与OS和ES的发生、发展及转移。阐明骨肿瘤复杂的病理机制能为OS和ES提供更有效的靶向治疗手段和降低患者的死亡率。
骨肿瘤的发生发展及转移
【摘 要】
：
骨肿瘤中骨肉瘤（OS）和尤文肉瘤（ES）因具有较复杂的发生、发展、转移机制和不良预后而受到医学界的广泛关注。研究表明原癌基因的激活和抑癌基因的突变、凋亡信号缺失和乏氧诱导因
【机 构】
：
吉林大学中日联谊医院骨外科
【出 处】
：
国际肿瘤学杂志
【发表日期】
：
2004年期
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