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在人体器官中,眼居于特殊地位、角膜和晶状体是药物作用极为徐缓的组织。视网膜的血液供应则不同,其内层近玻璃体侧的所谓脑层(含双极细胞和神经节细胞)是由视网膜中央动脉共给,此层的代谢特点及其血——网膜屏障与脑相同。视网膜的外层(包括感光细胞和色素上皮层)是由脉络膜动脉的毛细血管供养,这一血管区的血流量为20微升/分/克组织,较脑组织约多20倍。另外,视网膜和葡萄膜的黑色素含量很高。黑色素对多环的芳香族化合物具有高度的亲和力。黑色素含有无数自由价和自由基,因而具有离子交换和贮藏某些药物的作用,从而使感光细胞和色素上皮层的药物浓度高于其他组织。视网膜的血循环特点和黑色素含量均说明它在药物治疗过程中可单独
In human organs, the eye is in a special position, and the cornea and lens are very slow-acting tissues. Retinal blood supply is different, the inner layer of the so-called near the vitreous side of the brain (including bipolar cells and ganglion cells) by the central retinal artery, the metabolic characteristics of this layer and the blood - the omentum barrier and brain the same. The outer retina, including the photoreceptor cells and the pigment epithelium, is fed by capillaries of the choroidal artery, which have a blood flow of 20 microliters / minute / gram of tissue, about 20 times more than brain tissue. In addition, the retina and uveal melanin content is high. Melanin has a high affinity for polycyclic aromatic compounds. Melanin contains innumerable free valences and free radicals, which have the effect of ion exchange and storage of certain drugs, making the concentration of drug in photoreceptor cells and pigment epithelium higher than other tissues. Retinal blood circulation characteristics and melanin content shows that it can be used alone in the drug treatment process