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目的:探讨法安明联合维生素E对胎儿生长受限高危患者进行早期干预的临床疗效。方法:选择存在胎儿生长受限高危因素的孕妇共156例,研究组86例,每天皮下注射一次法安明5000U,同时给予天然维生素胶丸E0.1g,每天口服3次,可根据D-二聚体结果调整法安明用量直至降至正常,孕中期开始补钙。对照组70例,孕早期不干预,孕中期开始补钙。比较两组妊娠结局。结果:研究组分娩孕周、新生儿出生体重明显高于对照组,胎儿生长受限、羊水过少、妊娠期高血压疾病、新生儿窒息的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05);两组宫内死胎、围产儿死亡的发生率无差异(P>0.05)。结论:法安明联合维生素E对胎儿生长受限高危患者进行早期干预,可减少胎儿生长受限、羊水过少、妊娠期高血压疾病及新生儿窒息等的发生,改善妊娠结局及围生儿预后。
Objective: To investigate the clinical efficacy of combination of Emin combined with vitamin E on early intervention in high-risk fetal growth. Methods: A total of 156 pregnant women with risk factors for fetal growth restriction were selected. The study group consisted of 86 patients injected subcutaneously with Fumian 5000U per day and E0.1g capsules of natural vitamin E orally three times a day. Amoeba results adjustment method dose down to normal, the second trimester calcium. The control group of 70 cases, no intervention in the first trimester, the second trimester calcium supplement. Pregnancy outcomes were compared between the two groups. Results: The gestational age of the study group, newborn birth weight was significantly higher than the control group, fetal growth restriction, oligohydramnios, gestational hypertension, neonatal asphyxia were significantly lower than the incidence of the control group, the difference was Statistical significance (P <0.05). There was no significant difference in the incidence of stillbirth and perinatal death between the two groups (P> 0.05). Conclusion: The combination of vitamin E and FAM can prevent fetal growth restriction, oligohydramnios, hypertensive disorders of pregnancy and neonatal asphyxia, and improve pregnancy outcome and perinatal outcome Prognosis.