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正常乳腺组织与乳腺癌组织的红外光谱之间存在明显而规律的差异 ,其中包括蛋白质与核酸等生物分子的氢键缔合方式和程度上的不同。光谱的变化主要表现在 :( 1)蛋白质的酰胺Ⅰ带 ,N—H基团和某些氨基酸残基上C—O(H)基团的振动谱带 ;( 2 )核酸分子中磷酸二酯的反对称伸缩振动谱带和配对的碱基N—H基团振动等谱带上。氢键是维系和促进蛋白质与核酸高级结构形成的重要作用力 ,癌变时氢键的变化与癌细胞的特殊生物学行为密切相关 ,因此有可能利用氢键的这些光谱特征作为乳腺癌诊断和预测癌变可能性的指标。
There are obvious and regular differences between the infrared spectra of normal breast tissues and breast cancer tissues, including the hydrogen bonding patterns and the degree of the differences of the biological molecules such as proteins and nucleic acids. The changes of the spectrum are mainly as follows: (1) the vibrational bands of amide Ⅰ, N-H and C-O (H) groups on some amino acid residues of the protein; (2) Of the antisymmetric stretching vibration band and the paired base N-H group vibration band. Hydrogen bonding is an important force to maintain and promote the formation of high-order structures of proteins and nucleic acids. The changes of hydrogen bonds during carcinogenesis are closely related to the special biological behaviors of cancer cells. Therefore, it is possible to use these spectral characteristics of hydrogen bonding as a diagnostic and prognostic factor for breast cancer Indicators of the possibility of cancer.