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采用 HPLC法测定 10名健康志愿者单剂量口服克拉霉素片 5 0 0 mg后血药浓度 ,药 -时数据经 3p87程序处理 ,得到克拉霉素片的药动学参数分别为 :lagtime0 .30± 0 .11h,t1 /2 k0 .6 5± 0 .2 9,Tmax2 .15± 0 .44h;Cmax2 .2 1± 0 .1ug/ ml;T1 /2 k3 .18± 0 .6 5 h;V/ F15 0 .49± 18.19L,AUC16 .42± 2 .11μg· h/ ml
Pharmacokinetic parameters of clarithromycin tablets were determined by HPLC method after the single-dose orally taken clarithromycin tablets of 50 healthy volunteers were determined by 3p87 program. The pharmacokinetic parameters were: lagtime0 .30 ± 0.01 h, t1 / 2 k0.65 ± 0.29, Tmax2.15 ± 0.44 h, Cmax2.2 ± 0.1 μg / ml, T1 / 2 k3.18 ± 0.56 h, V / F15 0.49 ± 18.19L, AUC16.42 ± 2.11μg · h / ml