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目的 了解类风湿关节炎 (RA)患者血清血管内皮细胞生长因子 (VEGF)与病情活动性的相关性以探讨其临床意义。方法 采用酶联免疫吸附试验 (ELISA)方法检测RA患者活动组 (30例 )、缓解组 (30例 )及正常对照组 (30名 )的血清VEGF ,并分析血清VEGF与RA病情活动指标之间的关系。结果 活动组RA患者血清VEGF(183± 5 6 )ng L显著高于缓解组 (84± 8)ng L及正常对照组 (82± 8)ng L (P <0 0 1) ;活动组患者血清VEGF浓度与RA病情活动指标C反应蛋白 (CRP) (r=0 711,P <0 0 0 1)及Stoke指数 (r=0 6 38,P <0 0 0 1)呈显著正相关 ,与类风湿因子 (RF) (r=0 16 1,P >0 0 5 )、血沉 (ESR) (r=0 12 8,P >0 0 5 )、双足双手X线狭窄侵蚀积分 (r=- 0 0 11,P >0 0 5 ;r=0 0 2 4 ,P >0 0 0 5 )无相关性。与反应RA活动期指标血清透明质酸 (HA)、可溶性白细胞介素 2受体 (sIL 2R)、白细胞介素 2 (IL 2 )相比 ,VEGF判断RA活动期的敏感性为 93 3% ,特异性为 93 3%。结论 血清VEGF与RA的病情活动性有关 ,检测血清VEGF有助于RA活动性判断
Objective To investigate the correlation between serum vascular endothelial growth factor (VEGF) and disease activity in patients with rheumatoid arthritis (RA) to explore its clinical significance. Methods Serum levels of VEGF were measured by enzyme linked immunosorbent assay (ELISA) in 30 patients with active RA (30 patients), 30 patients with remission (RA) and 30 normal controls (RA) Relationship. Results The serum level of VEGF (183 ± 56) ng L in active RA patients was significantly higher than that in remission patients (84 ± 8) ng L and normal controls (82 ± 8) ng L (P <0.01) There was a significant positive correlation between the concentration of VEGF and C reactive protein (CRP) (r = 0 711, P 0 01) and Stoke index (r 0 068, P 0 01 0) in patients with RA The scores of rheumatoid factor (RF) (r = 0 16 1, P 0 05), ESR (r 0 12 8, P 0 05) 0 11, P> 0 0 5; r = 0 0 2 4, P> 0 0 0 5) no correlation. Compared with serum HA, soluble IL-2R and IL-2, the sensitivity of VEGF to RA activity was 93.3% The specificity is 93 3%. Conclusions Serum VEGF is associated with the activity of RA, and the detection of serum VEGF contributes to the judgment of RA activity