论文部分内容阅读
目的 :通过测定肺癌患者围手术期外周血清白细胞介素 - 8(interleukin- 8,IL- 8)、白细胞介素 - 10 (interleukin- 10 ,IL- 10 )和转化生长因子 - β1 (transform ing growth factor- β1 ,TGF- β1 )的水平 ,探讨其与肺癌的关系及临床意义。方法 :用酶联免疫吸附法 (EL ISA法 )测定了 32例肺癌患者手术前后及 2 0例健康人血清 IL- 8、IL- 10和 TGF- β1 水平。结果 :肺癌组术前 IL- 8、IL- 10和 TGF- β1 水平明显高于健康对照组 ,差异有显著性 (P<0 .0 1) ,且血清 IL- 8、IL- 10和 TGF- β1水平与肺癌的TNM分期有关 ,随肺癌的进展其水平逐步增高 (P<0 .0 1) ,与其病理分型无关 (P>0 .0 5 )。肺癌组术后其 IL- 8、IL- 10和 TGF- β1 水平较术前明显下降 (P<0 .0 1) ,但仍高于健康对照组 (P<0 .0 1)。结论 :肺癌患者存在免疫功能异常 ;肺癌切除术后 ,可以改善患者的免疫功能状态 ;动态观察 IL- 8、IL- 10和TGF- β1 水平将有助于肺癌的诊断及疗效评价 ,并可为肺癌的免疫治疗提供依据。
OBJECTIVE: To determine the effect of perioperative peripheral blood serum interleukin-8 (IL-8), interleukin-10 (IL-10) and transforming growth growth factor-β1 factor-β1, TGF-β1) levels, explore its relationship with lung cancer and clinical significance. Methods: Serum levels of IL-8, IL-10 and TGF-β1 in 32 patients with lung cancer before and after operation and 20 healthy people were measured by ELISA. Results: The levels of IL-8, IL-10 and TGF-β1 in lung cancer group before operation were significantly higher than those in healthy control group (P <0.01), and the levels of IL-8, IL- The level of β1 was correlated with the TNM stage of lung cancer and gradually increased with the progress of lung cancer (P <0.01), but not with the pathological type (P> 0.05). The levels of IL-8, IL-10 and TGF-β1 in the lung cancer group were significantly lower than those before the operation (P <0.01), but still higher than those in the healthy control group (P <0.01). CONCLUSIONS: There is abnormal immune function in patients with lung cancer. After resection of lung cancer, the immune status of patients can be improved. The dynamic observation of the levels of IL-8, IL-10 and TGF-β1 will be helpful for the diagnosis and evaluation of lung cancer. Immunotherapy of lung cancer provide the basis.