论文部分内容阅读
目的探讨妊娠期糖尿病(GDM)患者血清瘦素(leptin)水平与胰岛素抵抗的关系。方法选择26例GDM患者为观察组,32例糖耐量正常的健康妊娠妇女(NGT)为对照组,两组均行75 g葡萄糖耐量试验(OGTT),同时测定空腹血浆胰岛素(FINS)和血清瘦素(leptin)水平,计算胰岛素抵抗指数(HOMA-IR),并应用pearson分析妊娠期糖尿病患者胰岛素抵抗与瘦素、空腹胰岛素、体重指数(BMI)的关系。结果 GDM组血清瘦素(leptin)、胰岛素(FINS)及胰岛素抵抗指数均明显高于NGT组(P<0.05或P<0.01);血清瘦素、FINS、BMI与HOMA-IR呈正相关(P<0.01)。结论瘦素是影响妊娠期糖尿病患者胰岛素抵抗的独立危险因子。
Objective To investigate the relationship between serum leptin level and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods Twenty-six patients with GDM were selected as observation group and 32 healthy pregnant women with normal glucose tolerance (NGT) as control group. All patients were given 75 g glucose tolerance test (OGTT), fasting plasma insulin (FINS) and serum lean (HOMA-IR) were calculated and the relationship between insulin resistance and leptin, fasting insulin and body mass index (BMI) in gestational diabetes mellitus was analyzed by pearson. Results Serum leptin, insulin (FINS) and insulin resistance index of GDM group were significantly higher than that of NGT group (P <0.05 or P <0.01). Serum leptin, FINS and BMI were positively correlated with HOMA-IR (P < 0.01). Conclusion Leptin is an independent risk factor for insulin resistance in gestational diabetes mellitus.