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目的观察黄柏胶囊联合克拉霉素治疗对慢性宫颈炎患者血清相关因子水平的影响。方法将216例慢性宫颈炎患者随机分为试验组和对照组各108例。2组患者均给予保妇康栓常规治疗和克拉霉素抗感染,试验组另加用黄柏胶囊治疗。分别于治疗前后检测2组患者血清超氧化物歧化酶(SOD)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)水平,比较其变化差异。结果治疗前试验组患者血清SOD、hs-CRP和TNF-α水平与对照组相近(P>0.05)。治疗后2组各项指标水平均呈降低趋势,且试验组降低程度大于对照组,差异均有统计学意义(P<0.05)。结论黄柏胶囊联合克拉霉素治疗慢性宫颈炎可有效降低患者血清SOD、hs-CRP和TNF-α水平。
Objective To observe the effect of Huangbai capsule combined with clarithromycin on serum levels of serum related factors in patients with chronic cervicitis. Methods 216 cases of chronic cervicitis were randomly divided into experimental group and control group of 108 cases. Two groups of patients were given Baofukang suppository conventional treatment and clarithromycin anti-infection, the experimental group plus Huangbai capsule treatment. The serum levels of superoxide dismutase (SOD), hs-CRP and TNF-α were measured before and after treatment respectively. The differences were compared. Results Before treatment, the levels of serum SOD, hs-CRP and TNF-α in the test group were similar to those in the control group (P> 0.05). After treatment, the level of each index in both groups showed a decreasing trend, and the degree of reduction in the experimental group was greater than that in the control group, with significant differences (P <0.05). Conclusion Huangbai capsule combined with clarithromycin can effectively reduce the level of serum SOD, hs-CRP and TNF-α in patients with chronic cervicitis.