论文部分内容阅读
目的研究内分泌腺来源的血管内皮生长因子(EG-VEGF)在多囊卵巢的表达,并与血管内皮生长因子(VEGF)的表达进行比较,探讨EG-VEGF在多囊卵巢综合征(PCOS)发病机制中的作用。方法采用免疫组化SP法检测多囊卵巢及正常卵巢组织中EG-VEGF及VEGF的表达情况。结果 EG-VEGF在研究组中的表达水平显著高于对照组(P=0.001)。VEGF在研究组中的表达水平明显高于对照组(P=0.021)。研究组中EG-VEGF的表达水平高于VEGF的表达水平(P=0.036),二者表达无相关性(P=0.327)。对照组中EG-VEGF的表达水平略高于VEGF的表达水平,但差异无统计学意义(P=0.655),二者表达仍无相关性(P=0.928)。结论 EG-VEGF蛋白的过度表达促进多囊卵巢综合征患者的血管生成,与多囊卵巢综合征的发生相关。
Objective To investigate the expression of endocrine-derived vascular endothelial growth factor (VEGF-VEGF) in polycystic ovary and to compare with the expression of vascular endothelial growth factor (VEGF), and to explore the role of EG-VEGF in the pathogenesis of polycystic ovary syndrome (PCOS) Mechanism of the role. Methods Immunohistochemical SP method was used to detect the expression of EG-VEGF and VEGF in polycystic ovary and normal ovary tissues. Results The expression of EG-VEGF in the study group was significantly higher than that in the control group (P = 0.001). The expression of VEGF in the study group was significantly higher than that in the control group (P = 0.021). The expression of EG-VEGF in the study group was higher than that in VEGF (P = 0.036), but there was no correlation between the expression of EG-VEGF and the expression of VEGF (P = 0.327). The expression of EG-VEGF in the control group was slightly higher than that in VEGF, but the difference was not statistically significant (P = 0.655). There was no correlation between the expression of EG-VEGF and control group (P = 0.928). Conclusion The overexpression of EG-VEGF protein promotes angiogenesis in patients with PCOS and is associated with the occurrence of PCOS.