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目的:建立犬海水浸泡性胸部开放伤实验模型,探讨致伤机理及早期死亡原因.方法:20只成年杂犬随机分为2组.实验动物致伤后随机分为单纯胸外伤组(n=10)和海水浸泡组(n=10).海水浸泡组动物于伤后置入人工配制的海水中,实验中监测血液动力学、呼吸系统和动脉血气变化.结果:海水浸泡组死亡率明显高于单纯胸外伤组,并且生存时间明显短于单纯胸外伤组,平均生存时间为45min.结论;本实验模型致伤精度高,重复性好,创伤后造成的呼吸循环功能改变与胸部火器伤所见相符,适用于海水浸泡性胸外伤的早期病理生理研究.急性呼吸和循环功能衰竭以及严重酸中毒(代谢性+呼吸性)是早期死亡原因.
Objective: To establish a canine seawater-immersed open chest injury model to explore the mechanism of injury and the cause of early death.Methods: Twenty adult dogs were randomly divided into two groups.The experimental animals were randomly divided into simple thoracic injury group (n = 10) and seawater immersion group (n = 10) .The animals in the seawater immersion group were placed in artificially prepared seawater after the injury and the changes of hemodynamics, respiratory system and arterial blood gas were monitored in the experiment.Results: The mortality of the seawater immersion group was significantly higher In the simple thoracic trauma group, the survival time was significantly shorter than the simple thoracic trauma group, the average survival time was 45min.Conclusion: The experimental model of high precision and good repeatability, posttraumatic respiratory function and chest firearm injury See consistent, suitable for early pathophysiology of seawater-immersion thoracic injury.Acute respiratory and circulatory failure and severe acidosis (metabolic + respiratory) is the cause of early death.