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早在1912年Bowen氏报道2例“癌前性皮肤病变”,与现在已知的癌前期病变(如派杰氏病、着色性干皮病、X-线性皮炎和老年性角化病)在组织学上极其相似。故Bowen氏病实为鳞状细胞原位癌。现已证明该病与人乳头瘤病毒(简称HPV)16型特异性DNA有关。1958年以来,国内有28例报道,其中病程约为2个月～36年。病变范围为0.3×0.6cm～15×11cm。截至1990年国外共报道617例,男女之比为1.2:1,或0.8:1。该病可累及身体任何部位皮肤乃
As early as 1912 Bowen reported 2 cases of “precancerous skin lesions”, and now known precancerous lesions (such as Parker’s disease, xeroderma pigmentosum, X-linear dermatitis and senile keratosis) Histologically very similar. Therefore, Bowen’s disease is squamous cell carcinoma in situ. It has been shown that the disease is associated with human papillomavirus type 16 (HPV)-specific DNA. Since 1958, 28 cases have been reported in the country, and the course of the disease is about 2 months to 36 years. The lesion ranged from 0.3 x 0.6 cm to 15 x 11 cm. As of 1990, a total of 617 cases were reported abroad, and the ratio between men and women was 1.2:1, or 0.8:1. The disease can affect the skin of any part of the body