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目的:观察白介素-6(IL-6)在妊娠糖尿病(GDM)中的变化。方法:纳入2014年10月至2015年6月在福州市第一医院门诊就诊的妊娠妇女(孕周不定,妊娠前有糖尿病病史的孕妇排除实验对象),通过OGTT确诊有无妊娠期糖尿病,检测血糖、糖化血红蛋白(Hb A1c)、C反应蛋白(CRP)、白介素-6(IL-6)等相关指标。结果:妊娠糖尿病孕妇空腹血糖、餐后2小时血糖、Hb A1c大于正常组,其中C组、D组的空腹血糖、Hb A1c和A组的差异具有统计学意义(P<0.05);炎症因子方面,妊娠糖尿病孕妇C组、D组CRP高于A组,B组、C组、D组IL-6大于A组。结论:妊娠糖尿病孕妇,特别孕中晚期患者的IL-6水平高于正常妊娠妇女,可能有妊娠糖尿病存在一定的因果关系。
Objective: To observe the changes of interleukin-6 (IL-6) in gestational diabetes mellitus (GDM). METHODS: Pregnant women (uncertain gestational age, pregnant women with a history of diabetes before pregnancy) who underwent outpatient treatment in Fuzhou First Hospital from October 2014 to June 2015 were enrolled in this study. The gestational diabetes was diagnosed by OGTT. Blood glucose, glycosylated hemoglobin (Hb A1c), C-reactive protein (CRP), interleukin -6 (IL-6) and other related indicators. Results: The fasting blood glucose in pregnant women with gestational diabetes mellitus, Hb A1c at 2 hours after the meal was higher than that in the normal group, and the fasting blood glucose, Hb A1c and A in the C group and the D group were statistically significant (P <0.05) , Pregnant women with gestational diabetes C group, D group CRP higher than A group, B group, C group, D group IL-6 greater than A group. Conclusion: The levels of IL-6 in pregnant women with gestational diabetes mellitus, especially those in the middle and late stages of pregnancy, are higher than those in normal pregnant women and may have some causal relationship with gestational diabetes mellitus.