本文着重研究了微晶纤维素与硬脂酸镁混合的时间不同时,微晶纤维素的粒度对制剂性质的影响。实验用硬脂酸镁(C·P·Saarchem,Tohannesburg)平均粒度32.8μm,最大颗粒直径68.3μm。微晶纤维素(Avicel PIt102,FMC)平均粒度96μm,将其过筛分成三部分(80～180,180～250,250～300μm)。取不同部分的微晶纤维素30g和硬脂酸镁300g装入340ml的玻璃瓶中(直径60mm,长120 mm),用Turbula混合处理机混合(90r/min),混合时间为2～128分钟不 This article focuses on the different time of mixing microcrystalline cellulose and magnesium stearate, the particle size of microcrystalline cellulose on the nature of the preparation. The experimental magnesium stearate (C.P. Saarchem, Tohannesburg) had an average particle size of 32.8 μm and a maximum particle diameter of 68.3 μm. Microcrystalline cellulose (Avicel PIt 102, FMC) had an average particle size of 96 μm and was sieved into three fractions (80-180,180-250,250-300 μm). Different fractions of microcrystalline cellulose 30 g and magnesium stearate 300 g were taken into 340 ml glass bottles (60 mm in diameter and 120 mm in length), mixed (90 r / min) with a Turbula mixing processor for 2 to 128 minutes Do not