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镁盐的急性中毒及其解救是实验学的重要内容。经实验,镁盐对家兔有急性中毒作用,钙盐有解救作用,钙离子对镁离子有拮抗作用。过去进行此项实验时,用传统硫酸镁注射法,存在一些缺点,药物起效时间长,用药量大,反应不典型。最近我实验室将传统肌肉注射法改用静脉注射法进行对比实验,发现药物起效时间,用药剂量,反应效果有明显不同,补充了肌肉注射法的缺点。
Acute poisoning of magnesium salt and its rescue is an important part of experimental science. After experiments, magnesium salt has acute poisoning effect on rabbits, calcium salt has a rescue effect, and calcium ions have antagonistic effects on magnesium ions. In the past to carry out this experiment, the traditional magnesium sulfate injection method, there are some shortcomings, the drug takes a long time, the amount of medication, the reaction is not typical. Recently my laboratory will be the traditional method of intramuscular injection instead of intravenous contrast experiments and found that the onset time of the drug, the dose, the response was significantly different, complementing the shortcomings of intramuscular injection.