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在啮齿类动物中使用抗CD_4单抗表明可以防止和逆转自发和实验诱导的自身免疫病、延迟器官和皮肤移植的排斥反应。本文作者没有进行抗CD_4单抗免疫抑制作用的专门实验室研究,主要评估了抗CD_4单抗的生物学效应及临床副作用。作者在肾移植患者中选择了12名自愿实验者(男9名,女3名)。实验前都曾用硫唑嘌呤和强的松龙抑制免疫功能。实验方法是术后24小时静脉输入BL_4,持续1小时以上,5名患者的使用剂量是10mg/天,另7名是15mg/天,疗程3～14天(平均5天)。结果:3例进行了2周治疗,无排斥
The use of anti-CD4 mAbs in rodents has shown to prevent and reverse spontaneous and experimentally induced autoimmune diseases and delay rejection of organs and skin grafts. The authors do not have a specific laboratory study on the immunosuppressive effects of anti-CD 4 mAb, mainly evaluating the biological effects and clinical side effects of anti-CD 4 mAb. The authors selected 12 volunteer experimenters (9 males and 3 females) in renal transplant recipients. Before the experiment with azathioprine and prednisolone inhibition of immune function. The experimental method is to inject BL_4 intravenously 24 hours after operation for more than 1 hour. The dosage for 5 patients is 10 mg / day, and the other 7 are 15 mg / day for 3 to 14 days (average 5 days). Results: Three patients were treated for 2 weeks without rejection