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目的研究高砷水区人群血中氧化与抗氧化能力的影响,探讨高砷水对机体的危害及机理。方法对不同人群血中超氧化物歧化酶(SOD)总量、谷胱甘肽过氧化物酶(GSH鄄Px)、谷胱甘肽(GSH)和脂质过氧化物(LPO)进行测定和分析。结果SOD随饮水砷浓度增高而代偿性增高,在36～55岁年龄段最明显,该年龄段对照组LPO明显低于高水砷组(P<0.05);GSH对照组高于高水砷组(P<0.05);GSH鄄Px变化不大,只有55岁以上年龄段对照组高于高水砷组。结论饮用高砷水可影响机体氧化与抗氧化系统,在轻中度砷中毒时,可引起抗氧化物代偿性增加和脂质过氧化的发生,并对机体造成损伤。
Objective To study the effects of oxidative and anti-oxidative activities in the blood of high-arsenic water population and to explore the harm and mechanism of high-arsenic water on the body. Methods The levels of total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) and lipid peroxidation (LPO) in different populations were measured and analyzed . Results SOD increased with the increase of arsenic concentration in drinking water, which was the highest in 36-55 years old group. LPO in control group was significantly lower than that in high water arsenic group (P <0.05) Group (P <0.05). GSH-Px did not change much, only the control group aged over 55 was higher than the high-water arsenic group. Conclusion Drinking high-arsenic water can affect the body’s oxidation and anti-oxidant system. When it is mild to moderate arsenic poisoning, it can cause compensatory increase of anti-oxidants and lipid peroxidation and cause damage to the body.