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本文对喂服不同剂量棉酚后大鼠和豚鼠肾皮质细胞膜组分中的Na-K-ATP酶的活性变化进行了分析。结果表明:大鼠及豚鼠喂服棉酚(5mg/d×56、10mg/d×28、15mg/d×48)后,肾皮质细胞膜组分中与Na-K-ATP酶特异结合的~3H-哇巴因的量,随棉酚药量增加而有减少趋势,但服药组与对照组之间的差别无显著意义。但当豚鼠喂服棉酚与不同饲料(20mg/d+低钾饲料40～60mg/d+常规饲料)后,肾细胞膜及匀浆的Na-K-ATP酶活力,
In this paper, the changes of Na-K-ATPase activity in the membrane fractions of renal cortex of rats and guinea pigs fed with different doses of gossypol were analyzed. The results showed that gossypol (5 mg / d × 56, 10 mg / d × 28, 15 mg / d × 48) was administered to rats and guinea pigs, and ~ 3H The amount of ouabain decreased with the increase of gossypol dose, but there was no significant difference between medication group and control group. However, when guinea pigs fed gossypol with different diets (20mg / d + 40-60mg / d of low-K diets + conventional diet), Na-K-ATPase activity in renal cell membrane and homogenate,