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胰岛素样生长因子 Ⅰ是一种与胰岛素原有高度同源性的生长调节激素 ,既具有胰岛素样代谢作用 ,又能促进组织细胞的生长与分化。IGF Ⅰ及其受体和结合蛋白 (IGFBP1 6)广泛存在于心血管系统中 ,能够促进心脏的生长发育、增强心脏功能 ,抑制心肌细胞凋亡 ,并在某些心血管疾病的发病机制中发挥极其重要的作用。IGF Ⅰ参与了动脉粥样硬化和高血压的发病过程 ,并与球囊扩张术后冠脉再狭窄密切相关 ,在缺血性心脏病中 ,IGF Ⅰ能促进受损心肌的修复 ,减轻心肌组织重构 ,改善心功能 ,对心脏起保护作用。
Insulin-like growth factor Ⅰ is a growth hormone with high homology with insulin, which not only has insulin-like metabolism, but also promotes the growth and differentiation of tissue cells. IGF Ⅰ and its receptor and binding protein (IGFBP1 6) are widely present in the cardiovascular system, which can promote the growth and development of the heart, enhance cardiac function, inhibit cardiomyocyte apoptosis and play a role in the pathogenesis of some cardiovascular diseases Extremely important role. IGF Ⅰ participates in the pathogenesis of atherosclerosis and hypertension and is closely related to coronary restenosis after balloon dilatation. In ischemic heart disease, IGF Ⅰ can promote the repair of damaged myocardium and relieve myocardial tissue Reconstruction, improve heart function, play a protective role on the heart.