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目的探讨空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)在糖尿病视网膜病变(DR)发生和发展中的临床意义。方法对44例2型糖尿病患者及20名正常人进行FBG、2hPBG、HbA1c水平检测,应用眼底荧光血管造影(FFA)进行DR的诊断、分期。将研究对象分为对照组、非糖尿病视网膜病变(NDR)组和非增殖性糖尿病视网膜病变(NPDR)组,NPDR组进一步分为DR-Ⅰ期、DR-Ⅱ期、DR-Ⅲ期。结果NPDR组2hPBG、HbA1c高于NDR组,差异具有统计学意义(P<0.05)。FBG水平NPDR组与NDR组之间差异无统计学意义(P>0.05)。结论DR的程度和进展与2hPBG、HbA1c水平相关,FBG并不是一个控制DR的理想监测指标。
Objective To investigate the clinical significance of fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG) and glycosylated hemoglobin (HbA1c) in the development and progression of diabetic retinopathy. Methods The levels of FBG, 2hPBG and HbA1c in 44 patients with type 2 diabetes mellitus and 20 normal subjects were measured. Fundus fluorescein angiography (FFA) was used to diagnose and stage DR. The subjects were divided into control group, non-diabetic retinopathy (NDR) group and non-proliferative diabetic retinopathy (NPDR) group. NPDR group was further divided into DR-Ⅰ, DR-Ⅱ and DR-Ⅲ stages. Results The levels of 2hPBG and HbA1c in NPDR group were significantly higher than those in NDR group (P <0.05). There was no significant difference between FBG level NPDR group and NDR group (P> 0.05). Conclusion The severity and progress of DR are correlated with 2hPBG and HbA1c levels. FBG is not an ideal monitoring indicator for DR.