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目的探究高效液相色谱法(HPLC)检测羊水L/S比值在判断胎肺成熟度中的应用。方法选取2012年9月~2013年9月在本院产科住院的妊娠满28周的孕妇120例作为研究对象,将患者分为对照组和观察组,每组60例患者,观察组患者采用HPLC检测法进行L/S比值测定胎肺成熟度,对照组患者采用泡沫实验测定胎肺成熟度。结果观察组的测定胎肺成熟度(88.33%)明显好于对照组的测定胎肺成熟度(63.33%),差异具有统计学意义(P<0.05)。观察组的敏感度(98.00%)、特异度(98.50%)明显好于对照组的敏感度(72.90%)、特异度(73.00%),差异有统计学意义(P<0.05)。结论 HPLC检测法进行羊水L/S比值测定以判定胎肺成熟度比采用一般的方法进行判定胎肺成熟度更能取得良好的检测结果,能够对胎儿肺表面的含量准确的有所了解,有效的预防新生儿的呼吸窘迫综合征,极大程度的提高胎儿的健康水平,值得在临床的检测中广泛推广应用。
Objective To investigate the application of high performance liquid chromatography (HPLC) in detecting amniotic fluid L / S ratio in determining fetal lung maturity. Methods A total of 120 pregnant women, who were hospitalized in our hospital from September 2012 to September 2013, were enrolled in this study. The pregnant women were divided into control group and observation group with 60 patients in each group. The patients in observation group were analyzed by HPLC Detection method for L / S ratio determination of fetal lung maturity, control group of patients using foam test fetal lung maturity. Results The observed fetal lung maturity (88.33%) in observation group was significantly better than that of control group (63.33%), the difference was statistically significant (P <0.05). The sensitivity (98.00%) and specificity (98.50%) of the observation group were significantly better than those of the control group (72.90%) and specificity (73.00%), respectively. The difference was statistically significant (P <0.05). Conclusion HPLC detection of amniotic fluid L / S ratio to determine the fetal lung maturity than the use of the general method to determine the fetal lung maturity better to obtain good test results, fetal lung surface content can be accurate to understand and effective The prevention of neonatal respiratory distress syndrome, to a great extent improve the health of the fetus, it is worth in the clinical testing widely used.