论文部分内容阅读
目的探讨应用肝细胞表面ASGPR流式细胞分析及临床指标建立肝储备功能定量评估系统,并与Child-Pugh评分进行比较,了解其在患者术前肝储备功能评估中的临床应用价值。方法选择32例肝占位病变行肝部分切除术患者,术前检测ICGR15与EHBF、R值与K值以及临床生化指标、Child-Pugh评分,以此作为自变量(Xn),以肝组织标本PHCASGPR+为因变量(Y),通过多元线性回归分析,建立肝储备功能定量评估系统,并与Child-Pugh评分进行比较,了解两种方法预测术后肝功能代偿情况的准确率。按照回归方程计算46例肝占位病变接受肝部分切除术及肝硬化并门脉高压症接受断流术患者肝储备功能定量值,评估肝储备功能情况,预测术后肝功能恢复情况,比较术前不同Child-Pugh分级与Y值患者术后肝功能恢复情况。结果在预测术后肝功能代偿良好准确率方面,Y值优于ChildPugh分级(P=0.030);而在预测术后肝功能代偿不良准确率方面,Y值与Child-Pugh分级无统计学差异(P=1.000)。结论新肝储备功能定量评估系统能一定程度提高肝切除或肝硬化患者术前肝储备功能评价准确度,具有临床应用价值。
OBJECTIVE: To establish a quantitative evaluation system of liver function using ASGPR flow cytometry and clinical indicators on the surface of hepatocytes, and to compare with Child-Pugh score to evaluate its clinical value in preoperative evaluation of liver reserve function. Methods 32 patients with hepatic lesions underwent partial hepatectomy. ICGR15 and EHBF, R and K values, clinical and biochemical parameters and Child-Pugh scores were measured before operation as the independent variable (Xn) PHCASGPR + as the dependent variable (Y), through the multiple linear regression analysis, to establish a quantitative evaluation system of liver reserve function, and compared with Child-Pugh score to understand the accuracy of the two methods to predict postoperative liver function compensation. According to the regression equation, the quantitative value of liver reserve function in 46 patients with liver space-occupying lesion undergoing partial hepatectomy and cirrhosis and portal hypertension undergoing liver bypass surgery was calculated, the liver reserve function was evaluated, the postoperative recovery of liver function was predicted, Preoperative different Child-Pugh grading and Y value of patients with liver function recovery. Results The Y value was superior to ChildPugh classification (P = 0.030) in predicting the good accuracy of compensated liver function after operation. However, there was no statistical significance between Y value and Child-Pugh classification in predicting the accuracy rate of postoperative liver function compensations Difference (P = 1.000). Conclusion The quantitative evaluation system of new liver reserve can improve the accuracy of preoperative liver reserve function evaluation in patients with liver resection or cirrhosis, and has clinical value.