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目的：探讨复方二氯二异丙胺治疗酒精性脂肪性肝病患者的临床疗效及安全性。方法将97例酒精性脂肪性肝病患者随机分为两组，研究组54例，对照组43例。研究组静脉滴注复方二氯二异丙胺治疗，对照组常规口服胰岛素增敏剂二甲双胍治疗，观察6周。于治疗6周末，根据血清总胆固醇改善状况判定临床疗效，并统计不良反应发生状况。结果治疗6周末，研究组总有效率为98．1％，对照组为81．4％；两组比较差异有极显著性（P＜0．01）。研究组不良反应发生率为7．4％，对照组为14．0％；两组比较差异无显著性（P＞0．05）。结论复方二氯二异丙胺治疗酒精性脂肪性肝病患者疗效显著，安全性高，值得在临床广泛推广应用。“,”Objective To explore the efficacy and safety of compound dichloride diisopropylamine (CDD) in the treatment of alcoholic fatty liver disease (AFLD) .Methods Ninety‐seven AFLD patients were randomly divided into research (n= 54) and control group (n= 43) .Research group was treated with intravenous CDD and control took orally insulin sensitizer metformin for 6 weeks .Effica‐cies were assessed according to the improvement condition of serum total cholesterol at the end of the 6th week and adverse reactions added up .Results At the end of the 6th week total effective rate was respec‐tively 9 8 .1% in research and 81 .4% in control group ,which showed significant difference ( P 0 .05) .Con‐clusion CDD has an evident effect and high safety in the treatment of AFLD and is worthy of clinical generalization and application .