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目的探讨活血化瘀法对肺癌放疗后放射性肺纤维化早期预防作用。方法选择2013年1月至2015年12月符合诊断标准的接受放疗的肺癌患者200例,随机分为观察组100例和对照组100例,观察组放疗后联合口服活血化瘀中药(血府逐瘀汤)治疗6个月,对照组单纯放疗。治疗后6个月,应用高分辨率CT观察放射性肺纤维化的发生情况,同时观察患者生命质量和血细胞相关指标。结果治疗6个月后,观察组肺纤维化明显低于对照组(χ~2=29.52,P<0.01)。观察组有64.0%的患者病情得到了缓解,而对照组中有48.0%的患者病情得到缓解,观察组疗效明显优于对照组(P<0.05)。生活质量评价:观察组的情绪方面评分明显优于对照组(t=4.711,P<0.01);在症状方面,观察组的恶心呕吐、乏力、失眠、呼吸困难、便秘、纳差、腹泻等评分均低于对照组(P<0.05,P<0.01),观察组的总体生活质量显著高于对照组(t=10.79,P<0.01)。观察组白细胞计数,血红蛋白含量和血小板值明显高于对照组(P均<0.05)。结论活血化瘀法对预防肺癌放疗引起的的肺纤维化损伤有很好的预防作用,同时提高患者生命质量,减轻了放疗不良反应,有较好的临床疗效。
Objective To investigate the early preventive effect of activating blood circulation and removing blood stasis method on radiation lung fibrosis after radiotherapy of lung cancer. Methods 200 patients with lung cancer undergoing radiotherapy from January 2013 to December 2015 were randomly divided into observation group (n = 100) and control group (n = 100). The observation group was treated with combined oral administration of traditional Chinese medicine for activating blood circulation and removing blood stasis Stasis) for 6 months, control group only radiotherapy. Six months after the treatment, the occurrence of radiation-induced pulmonary fibrosis was observed by high-resolution CT. At the same time, the quality of life and blood cell related indexes were observed. Results After 6 months of treatment, the pulmonary fibrosis in the observation group was significantly lower than that in the control group (χ ~ 2 = 29.52, P <0.01). In the observation group, 64.0% of the patients were relieved. However, 48.0% of the patients in the control group were relieved. The observation group was significantly better than the control group (P <0.05). Quality of life evaluation: The observation group’s emotion score was significantly better than the control group (t = 4.711, P <0.01); in the symptom group, the observation group’s nausea and vomiting, fatigue, insomnia, dyspnea, constipation, (P <0.05, P <0.01). The overall quality of life of the observation group was significantly higher than that of the control group (t = 10.79, P <0.01). The observation group, white blood cell count, hemoglobin content and platelet value was significantly higher than the control group (P all <0.05). Conclusion The method of promoting blood circulation and removing blood stasis can prevent lung fibrosis caused by radiotherapy of lung cancer and prevent it. At the same time, it can improve the life quality of patients and reduce the adverse reactions of radiotherapy. It has good clinical curative effect.