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目的探讨不同TNM分期胃癌组织中S100P、CD147及OCT4的表达及临床意义。方法通过免疫组织化学法检测54例胃癌组织、40例慢性胃炎和20例正常胃组织的S100P、CD147及OCT4的表达情况,并比较胃癌组织不同TNM分期的表达水平。结果胃癌组织中S100P表达阳性率显著低于正常组织和慢性胃炎组织,差异有统计学意义(P<0.05);胃癌组织中CD147、OCT4表达阳性率均高于正常组织和慢性胃炎组织,差异有统计学意义(P<0.05);S100PⅤ期阳性率显著低于Ⅰ、Ⅱ期,差异有统计学意义(P<0.05);CD147各分期阳性率均为100%,其中强阳性率显著高于弱阳性和中等阳性,差异有统计学意义(P<0.05);OCT4Ⅲ期、Ⅴ期阳性率均高于Ⅰ期,差异有统计学意义(P<0.05);有远处转移患者S100P、表达阳性率显著低于无远处转移患者,差异有统计学意义(P<0.05);有远处转移患者OCT4表达阳性率显著高于无远处转移患者,差异有统计学意义(P<0.05)。不同分化程度胃癌患者S100P、CD147、OCT4表达阳性率比较差异无统计学意义(P>0.05)。结论胃癌组织中S100P显著降低,CD147、OCT4表达显著升高,与胃癌患者TNM分期、远处转移有密切关系,与肿瘤分化程度无关。
Objective To investigate the expression and clinical significance of S100P, CD147 and OCT4 in different TNM staging gastric cancer. Methods The expressions of S100P, CD147 and OCT4 in 54 cases of gastric cancer, 40 cases of chronic gastritis and 20 cases of normal gastric tissues were detected by immunohistochemistry. The expression of S100P, CD147 and OCT4 in different gastric tissues was also compared. Results The positive rate of S100P in gastric cancer tissues was significantly lower than that in normal tissues and chronic gastritis tissues (P <0.05). The positive rates of CD147 and OCT4 in gastric cancer tissues were higher than those in normal tissues and chronic gastritis tissues (P <0.05). The positive rate of S100PⅤ was significantly lower than that of Ⅰ and Ⅱ (P <0.05). The positive rates of CD147 were 100%, and the positive rate of S100PⅤ was significantly higher than that of the weak (P <0.05). The positive rates of stage Ⅲ and stage Ⅴ of OCT4 were higher than those of stage Ⅰ (P <0.05). The positive rates of S100P in patients with distant metastasis (P <0.05). The positive rate of OCT4 in patients with distant metastasis was significantly higher than that in patients without distant metastasis (P <0.05). There was no significant difference in the positive rates of S100P, CD147 and OCT4 among patients with different degrees of differentiation (P> 0.05). Conclusion S100P is significantly decreased in gastric cancer tissues, and the expression of CD147 and OCT4 is significantly increased. It is closely related to the TNM stage and distant metastasis in gastric cancer patients, but not to the degree of tumor differentiation.