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为探讨骨矿含量（ＢＭＣ）及骨钙素（ＢＧＰ）测定在性早熟儿童骨骼发育状况的诊断、治疗及疗效考核上的价值，对８２例特发性性早熟女孩，采用单光子吸收法测定桡骨的ＢＭＣ，放射免疫分析法测定血清ＢＧＰ含量。于治疗前及治疗３～４个月后分别测定ＢＭＣ和ＢＧＰ，并与正常同龄儿进行对比。结果：性早熟女孩的ＢＭＣ及血清ＢＧＰ浓度大多较同龄儿显著增高。性早熟Ⅱ～Ⅲ期者ＢＭＣ为０４５２±００８０ｇ／ｃｍ，Ⅳ～Ⅴ期者为０５８５±００９８ｇ／ｃｍ（ｔ＝５３６２，Ｐ＜０００１），示病情越重、病程越长，增高也越明显。治疗后Ⅱ～Ⅲ期者ＢＭＣ降为０３９９±００９３ｇ／ｃｍ，Ⅳ～Ⅴ期者降为０５１９±００７０ｇ／ｃｍ，与治疗前相比，ｔ＝４１４１，Ｐ＜００１。血清ＢＧＰ浓度也均明显降低。表明经过治疗，随着病情缓解，这些指标会有明显改善。因此，ＢＭＣ及ＢＧＰ对性早熟患儿诊治及疗效考核有一定的临床价值。
In order to explore the value of bone mineral content (BMC) and osteocalcin (BGP) determination in the diagnosis, treatment and therapeutic evaluation of skeletal development in precocious children, 82 girls with idiopathic precocious puberty were examined by single photon absorption Radial BMC, radioimmunoassay method for the determination of serum BGP content. Before treatment and 3 to 4 months after treatment, BMC and BGP were measured and compared with normal peers. Results: The BMC and serum BGP concentrations of precocious girls were significantly higher than those of the same age group. The precocious puberty Ⅱ ~ Ⅲ BMC 0 452 ± 0 80g / cm, Ⅳ ~ Ⅴ of 08585 ± 098g / cm (t = 5 362, P <0 001), showing the disease The heavier, the longer the duration, the higher the more obvious. BMC decreased to 0399 ± 0093g / cm in stage Ⅱ ~ Ⅲ after treatment, and decreased to 0519 ± 0070g / cm in stage Ⅳ ~ Ⅴ, compared with before treatment, t = 4141, P <0 01. Serum BGP concentrations were also significantly lower. Show that after treatment, as the disease eased, these indicators will be significantly improved. Therefore, BMC and BGP in precocious puberty diagnosis and treatment of children with certain clinical value.