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目的分析结核性脑膜炎规范治疗的效果。方法选取2012年6月至2015年12月105例结核性脑膜炎患者,随机分为治疗组和对照组。治疗组给予规范治疗,对照组给予抗结核联合脱水治疗。治疗4周后观察两组患者的临床疗效及症状改善情况。结果治疗组痊愈率为62.26%,总有效率为98.11%,均显著高于对照组(38.46%、84.62%)。治疗组患者并发意识障碍、头痛、脑膜刺激征及脑神经损伤的比例明显低于对照组,差异有统计学意义(P<0.05)。治疗组患者并发脑积水、脑梗死、脑实质病变以及胸片结核的比例明显低于对照组,差异有统计学意义(P<0.05)。结论规范化治疗明显提高结核性脑膜炎患者的临床疗效。
Objective To analyze the effect of standardized treatment of tuberculous meningitis. Methods From June 2012 to December 2015, 105 patients with tuberculous meningitis were randomly divided into treatment group and control group. The treatment group was given standard treatment, while the control group was given antituberculosis combined dehydration therapy. After 4 weeks of treatment, the clinical efficacy and symptom improvement of the two groups were observed. Results The cure rate of the treatment group was 62.26%, the total effective rate was 98.11%, which was significantly higher than that of the control group (38.46%, 84.62%). The incidence of concomitant disturbance of consciousness, headache, meningeal irritation and cranial nerve injury in the treatment group was significantly lower than that in the control group (P <0.05). The proportion of patients with hydrocephalus, cerebral infarction, parenchymal lesions and chest X-ray in the treatment group was significantly lower than that in the control group (P <0.05). Conclusion Standardized treatment significantly improves the clinical efficacy of patients with tuberculous meningitis.