目的:分析重度子痫前期的相关高危因素及对母婴结局的影响。方法:回顾性分析2009年1月~2011年10月该院分娩的104例重度子痫前期患者的临床资料,选取同期住院分娩的正常妊娠孕妇105例作为对照组,对一般资料、并发症情况及孕产妇和围生儿的结局进行分析。结果:文化程度低、未行系统产前检查的孕妇重度子痫前期发病率增加。孕前体重指数及流产史与重度子痫前期的发病有明显的相关性。孕妇发病时间越早,病情越严重,早产儿的发生率明显增加,新生儿窒息、围生儿死亡方面重度子痫前期组高于对照组,指标的差别有统计学意义。结论:完善相应的预防和治疗手段,减少重度子痫前期及其并发症的发生,适时终止妊娠是降低孕产妇、围生儿病死率的关键。 OBJECTIVE: To analyze the risk factors associated with severe preeclampsia and the impact on maternal and infant outcomes. Methods: The clinical data of 104 patients with severe preeclampsia who were delivered from January 2009 to October 2011 in our hospital were retrospectively analyzed. 105 normal pregnant women who were hospitalized in the same period were selected as the control group. The general data, complications And maternal and perinatal outcomes were analyzed. Results: The educational level was low. The incidence of severe preeclampsia in pregnant women who did not undergo systematic prenatal examination increased. Pre-pregnancy body mass index and history of abortion and severe preeclampsia have a significant correlation. The earlier the onset of maternal disease, the more severe the disease, the incidence of premature children increased significantly, neonatal asphyxia and perinatal mortality in severe preeclampsia group was higher than the control group, the difference was statistically significant. Conclusion: To improve the corresponding prevention and treatment measures to reduce the incidence of severe preeclampsia and its complications, timely termination of pregnancy is the key to reduce maternal and perinatal mortality.