Objective:This study aims to investigate the effect of 4 different dialysate temperatures on blood pressure during hemodialysis for patients with hypertension.Methods:Using a self-controlled method,the patients’ body temperature was set as T.Accordingly,the dialysate temperature was set as 37 ℃,T+0.5 ℃,T,and T-0.5 ℃.The changes in blood pressure,heart rate,mean arterial pressure and dialysis-induced adverse reactions at the 4 different dialysate temperatures were consistently monitored.Results:Patients who received hemodialysis with 37 ℃ and T+0.5 ℃ dialysate demonstrated an unstable blood pressure and a higher incidence of adverse reactions,Patients who received hemodialysis with T and T-0.5 ℃ dialysate showed a relatively stable blood pressure,heart rate,and mean arterial pressure during dialysis.In particular,dialysate at T-0.5 ℃ resulted in the most stable blood pressure,the fewest adverse reactions and the best self-assessed comfort scores(P < 0.01).Conclusions:The dialysate temperature during hemodialysis for patients with hypertension should be set to a temperature based on patients’ preoperative body temperate T or 0.5 ℃ below T.This practice is suggested to enhance the stability of patients’ blood pressure and heart rate during hemodialysis,reduce complications and improve patients’ tolerance of hemodialysis. Objective: This study aims to investigate the effect of 4 different dialysate temperatures on blood pressure during hemodialysis for patients with hypertension. Methods: Using a self-controlled method, the patients’ body temperature was set as T. Accredially, the dialysate temperature was set as 37 ° C, T + 0.5 ° C, T, and T-0.5 ° C. The changes in blood pressure, heart rate, mean arterial pressure and dialysis-induced adverse reactions at the 4 different dialysate temperatures were. consistently felt. Results: Patients who received hemodialysis with 37 ℃ and T + 0.5 ℃ dialysate demonstrated an unstable blood pressure and a higher incidence of adverse reactions, Patients who hemodialysis with T and T-0.5 ℃ dialysate showed a relatively stable blood pressure, heart rate, and mean arterial pressure during dialysis. In particular, dialysate at T-0.5 ° C resulted in the most stable blood pressure, the fewest adverse reactions and the best self-assessed comfort scores (P <0.01) .Conclusions: The d ialysate temperature during hemodialysis for patients with hypertension should be set to a temperature based on patients ’preoperative body temperate T or 0.5 ° C below T.This practice is suggested to enhance the stability of patients’ blood pressure and heart rate during hemodialysis, reduce complications and improve patients’ tolerance of hemodialysis.