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目的：观察益欣康泰胶囊对高原红细胞增多症（ＨＡＰＣ）患者体内氧自由基代谢指标超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活力和丙二醛（ＭＤＡ）含量的影响。方法：在海拔３ ３００ｍ 地区选择１０２ 例ＨＡＰＣ患者进行了服用益欣康泰前后体内ＳＯＤ、ＧＳＨ—Ｐｘ 活性和血清中ＭＤＡ含量的测定。结果：表明该药能明显升高ＨＡＰＣ患者体内的ＳＯＤ与ＧＳＨ—Ｐｘ 活性（Ｐ＜ ００１），同时还有降低血中ＭＤＡ 含量的作用（Ｐ＜ ００１）。结论：说明益欣康泰对ＨＡＰＣ患者体内的氧自由基代谢失衡具有良好的调节和改善作用，这对今后ＨＡＰＣ的预防与治疗上将具有重要的药用价值
OBJECTIVE: To observe the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in the oxygen free radical metabolism index of patients with high altitude polycythemia (HAPC) in Yixin Kangtai capsule. The effect of MDA) content. METHODS: A total of 102 patients with HAPC were selected at an altitude of 3 300 m. The activity of SOD and GSH-Px and serum MDA levels were measured before and after taking Yixin Kangtai. Results: It was shown that the drug can significantly increase the activity of SOD and GSH-Px in patients with HAPC (P < 0 01), as well as the effect of lowering MDA content in blood (P < 0.01). Conclusion: It is indicated that Yixin Kangtai has a good regulation and improvement effect on the imbalance of oxygen free radical metabolism in HAPC patients, which will have important medicinal value for the prevention and treatment of HAPC in the future.