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目的探讨结肠癌术后复发的外科治疗及影响患者预后的因素。方法回顾性分析我院1997年1月至2005年12月外科治疗的102例结肠癌复发病例的临床资料。应用 SPSS 11.5对随诊资料进行统计学分析,采用 x~2检验分析其相关因素,Kaplan-Meier 法进行生存分析,Log-rank 检验进行统计学比较。应用 COX 比例风险模型进行多因素分析。结果单因素统计分析显示原发肿瘤梗阻情况、再手术前的癌胚抗原水平、复发部位的多少、复发间隔时间和再手术方式是影响预后的主要因素,多因素统计分析显示复发部位的多少,再手术方式是影响预后的最重要因素。结论积极的外科治疗,争取行根治性切除手术,可以延长复发性结肠癌患者的生存期。
Objective To investigate the surgical treatment of postoperative recurrence of colon cancer and the factors affecting the prognosis of patients. Methods A retrospective analysis of our hospital from January 1997 to December 2005 surgical treatment of 102 cases of colon cancer recurrence clinical data. The data of follow-up were analyzed by SPSS 11.5. The related factors were analyzed by x ~ 2 test. The Kaplan-Meier method was used for survival analysis and Log-rank test for statistical analysis. Cox proportional hazards model was used for multivariate analysis. Results The univariate statistical analysis showed that the primary tumor obstruction, the level of CEA before operation, the number of recurrence sites, the recurrence interval and reoperation were the main factors affecting the prognosis. Multivariate statistical analysis showed that the number of recurrence sites, Re-operation is the most important factor affecting the prognosis. Conclusions Active surgical treatment for radical resection can prolong the survival of patients with recurrent colon cancer.