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目的 研究结肠癌手术标本中 p2 7kipl表达以及在肿瘤预后中的临床意义。 方法 应用免疫组织化学SABC法检测结肠癌标本中 p2 7kipl、cyclin E、ki- 6 7的表达。 结果 结肠癌粘膜病变由良性向恶性转变 ,p2 7kipl表达的阳性率呈现逐渐降低的趋势 ;p2 7kipl的表达与结肠癌组织 Duke’s分期、cyclin E及 ki- 6 7的表达呈现负相关 ,与肿瘤的预后呈正相关。 结论 结肠癌组织中 ,p2 7kipl表达缺失的肿瘤组织恶性程度更高 ,肿瘤更具有恶性增殖、浸润和转移潜能 ,并且直接影响术后生存期。检测结肠癌 p2 7kipl的表达情况 ,可以了解粘膜癌变的恶性倾向以及结肠癌的生物学行为 ,并且有助于估计患者的预后 ,指导患者术后的综合治疗。
Objective To study the expression of p27kipl in colon cancer specimens and its clinical significance in tumor prognosis. Methods Immunohistochemical SABC method was used to detect the expression of p27kipl, cyclin E and ki-67 in colon cancer specimens. Results The positive rate of p27kipl in colorectal mucosal lesions changed from benign to malignant. The expression of p27kipl was negatively correlated with the expression of Dukes’ stage, cyclin E and ki- The prognosis was positively correlated. Conclusion In colon cancer tissues, the tumor tissue lacking p2 7kipl expression is more malignant and the tumor has more malignant proliferation, infiltration and metastasis potential, and directly affects the postoperative survival. To detect the expression of p2 7kipl in colon cancer, we can understand the malignant tendency of mucosal carcinogenesis and the biological behavior of colon cancer, and help to estimate the prognosis of patients and guide the comprehensive treatment of patients after surgery.