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目的:考察枸橼酸阿奇霉素注射液的稳定性,并预测其室温贮存有效期。方法:用分光光度法测定枸橼酸阿奇霉素注射液含量;用初均速法预测其有效期。结果:本品在室温、高温条件下稳定;在光照下色泽变深,含量及pH有较明显变化。室温贮存有效期为11个月。结论:枸橼酸阿奇霉素注射液应闭光保存。
OBJECTIVE: To investigate the stability of azithromycin citrate injection and to predict its shelf life at room temperature. Methods: The content of azithromycin citrate injection was determined by spectrophotometry. The expiration date was estimated by the method of initial average velocity. Results: The product is stable under the condition of room temperature and high temperature. The color of the product becomes darker under light and the content and pH have obvious changes. Room temperature storage is valid for 11 months. Conclusion: Azithromycin citrate injection should be kept light.