近来 ,随着Ｈ2 受体拮抗药的广泛应用 ,出现了一些少见的不良反应 ,现综述如下。1　精神异常3例女患者 ,年龄 66～ 96岁 ,因上消化道出血 ,用西咪替丁2 0 0ｍｇ ,静脉滴注 ,分别在第 2 ,第 3天出现精神兴奋、胡言乱语、定向障碍、幻觉等症状 ,停用西咪替丁后以上症状消失[1] 。 Recently, with the widespread use of H2 receptor antagonists, there have been some rare adverse reactions, are summarized below. 1 mental abnormalities Three female patients, aged 66 to 96 years, due to upper gastrointestinal bleeding, with cimetidine 200 mg, intravenous infusion, respectively, in the first two days, three days of mental excitement, nonsense, orientation Disorders, hallucinations and other symptoms, the withdrawal of cimetidine symptoms disappear [1].