病毒感染人体后,病毒与宿主之间即开始相互斗争、相互作用。除了人们熟知的机体免疫系统能产生特异的细胞免疫和体液免疫反应以清除病毒外,近年发现宿主细胞的某些基因产物,如P53蛋白,也参与了抗病毒机制。P53蛋白是一种肿瘤抑制因子,可诱导细胞凋亡,以限制病毒生长,并能直接抑制病毒复制。此外,病毒对P53蛋白也有反作用。本文就宿主细胞编码的P53蛋白与某些病毒之间的相互作用作一综述。 After the virus infects the human body, the virus and the host begin to fight each other and interact with each other. In addition to the well-known immune system of the body that produces specific cellular and humoral immune responses to clear the virus, it has been found in recent years that certain gene products of host cells, such as P53 protein, are also involved in the anti-viral mechanism. P53 protein is a tumor suppressor that induces apoptosis to limit virus growth and directly inhibits virus replication. In addition, the virus also has a negative effect on P53 protein. This review summarizes the interactions between host cell-encoded P53 proteins and certain viruses.