观察泻心汤对正常、四氧嘧啶 (AL X)致糖尿病 (DM)小鼠及地塞米松致胰岛素抵抗 (IR)、糖耐量减退 (IGT)、模型大鼠的影响。结果表明 :泻心肠能拮抗 AL X诱导的小鼠高血糖 ,明显降低正常小鼠 AL X- DM模型小鼠的空腹血糖 (FBG) ,改善地塞米松致 IR大鼠模型的 IGT,降低病鼠的 FBG及口服葡萄糖 (OGTT)后 2 h血糖 (2 h BG)。提示泻心肠具有类似磺脲类药物和双胍类药物的降糖作用 Observed the effect of Xiexin Decoction on normal, alloxan (AL X)-induced diabetic (DM) mice and dexamethasone induced insulin resistance (IR), impaired glucose tolerance (IGT), and model rats. The results showed that Xiexinchang can antagonize ALX-induced hyperglycemia in mice, significantly reduce fasting blood glucose (FBG) in normal mouse AL X-DM model mice, improve IGT in dexamethasone-induced IR rat model, and reduce disease The FBG and oral glucose (OGTT) 2 h after blood glucose (2 h BG). Tips Xiexin has similar hypoglycemic effects with sulfonylureas and biguanides