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目的通过对一组癌性恶病质病例的统计分析,探讨EPA联合甲地孕酮治疗癌性恶病质的临床效果。方法对临床60例癌性恶病质患者采用EPA联合甲地孕酮的治疗方案,对比治疗前后总蛋白、清蛋白、体重的变化。结果治疗前,患者总蛋白、清蛋白、体重分别为(51.38±1.67)g/L、(30.55±2.37)g/L及(42.11±4.2)kg;治疗后,分别(58.18±4.43)g/L,(36.12±3.25)g/L、(45.14±4.96)kg,治疗前后对比,差异明显(P<0.05),具有统计学意义。PS评分由3分下降到2分。结论 EPA联合甲地孕酮的治疗方案,对于改善甚至逆转癌性恶病质具有一定的临床效果。
Objective To investigate the clinical effect of EPA combined with megestrol in the treatment of cancerous cachexia by statistical analysis of a group of cancerous cachexia cases. Methods Sixty patients with cancer cachexia were treated with EPA combined with megestrol. The changes of total protein, albumin and body weight before and after treatment were compared. Results Before treatment, total protein, albumin and body weight were (51.38 ± 1.67) g / L, (30.55 ± 2.37) g / L and (42.11 ± 4.2) L, (36.12 ± 3.25) g / L, (45.14 ± 4.96) kg respectively. There was significant difference between before and after treatment (P <0.05), which was statistically significant. PS score from 3 to 2 points. Conclusion The combination of EPA and megestrol therapy has certain clinical effect on improving or even reversing cancerous cachexia.