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目的研究槲皮素对AlCl3致衰老模型小鼠记忆障碍的保护作用及其机制分析。方法以AlCl3(60 mg/kg皮下注射7 d)造成小鼠记忆障碍模型,采用小鼠避暗试验和跳台试验,观察槲皮素(20、10、5 mg/kg灌胃15 d)对记忆障碍模型小鼠的保护作用,并于第16天对各剂量组小鼠进行脑组织超氧化物歧化酶(SOD)活性及血浆和脑组织谷胱甘肽过氧化物酶(GSH-PX)活性测定。结果槲皮素各个剂量组均能明显改善AlCl3所致被动回避性记忆障碍,增加SOD和GSH-PX活性。结论槲皮素对AlCl3致衰老小鼠记忆障碍有保护作用,其作用机制可能是通过增强抗氧化酶GSH-PX和SOD活性,清除氧自由基对中枢神经系统神经细胞的损伤。
Objective To study the protective effect of quercetin on memory impairment in AlCl3-induced aging mice and its mechanism analysis. Methods A mouse model of memory impairment was induced with AlCl3 (subcutaneously injected at 60 mg/kg for 7 d). The mouse dark test and step-down test were used to observe the effects of quercetin (20, 10, and 5 mg/kg for 15 d) on memory. The protective effect of the obstructive model mice, and on the 16th day, the superoxide dismutase (SOD) activity in the brain tissue and the glutathione peroxidase (GSH-PX) activity in the plasma and brain tissues of mice in each dose group. Determination. Results All doses of quercetin could significantly improve the passive avoidance memory impairment induced by AlCl3 and increase the activities of SOD and GSH-PX. Conclusion Quercetin has protective effects on memory impairment in aging mice induced by AlCl3. Its mechanism may be through the enhancement of anti-oxidative enzymes GSH-PX and SOD activity and the scavenging of oxygen free radicals on nerve cells in the central nervous system.