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为了寻找具有生物活性的新化合物,创制含氟吡啶类农药中间体,以廉价吡啶为起始原料,经Chichibabin反应、硝化,氨基保护和还原制得2-乙酰胺基-5-氨基吡啶,再经“一锅法”重氮化及席曼反应引入氟原子等步骤合成含氟吡啶中间体2-氨基-3-硝基-5-氟吡啶,优化了反应条件和后处理方式,产品纯度为97.8%,总产率为7.2%,结构经GC-MS、IR、1HNMR和13CNMR表征。
In order to search for new compounds with biological activity, this paper aimed to create 2-acetylamino-5-aminopyridine by fluoridated pyridine pesticide intermediates, using cheap pyridine as starting material, Chichibabin reaction, nitration and amino protection and reduction The reaction of 2-amino-3-nitro-5-fluoropyridine, a fluorinated pyridine intermediate, was synthesized by the method of “one-pot method” diazotization and Schiffmann reaction introduction of fluorine atom. The reaction conditions and the post- The purity was 97.8% and the total yield was 7.2%. The structures were characterized by GC-MS, IR, 1HNMR and 13CNMR.