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目的调查中国不同区域婴儿抗百日咳、白喉、破伤风母体抗体水平。方法在10年内分别在中国6个不同区域,对3月龄左右未接种过百白破联合疫苗(DPT)的健康婴儿体内抗百日咳、白喉、破伤风抗体水平进行了8次调查。分别检测了抗百日咳凝集原(Aggs)抗体1 602人,抗百日咳毒素(PT)和抗丝状血凝素(FHA)抗体790余人,白喉、破伤风抗体1 196人。结果未接种过DPT健康婴儿体内的抗百日咳Aggs抗体和抗PT、FHA抗体都分别<1∶320和<20EU/ml的保护水平;抗白喉、抗破伤风抗体水平都<0.01HAU/ml的保护水平,而且在婴儿群体中这种低抗体水平不随时间、不依城市或农村、发达地区或不发达地区而变化。结论DPT的初免月龄建议提前至2月龄,推广使用无细胞DPT,在低龄婴儿达到有效预防百日咳、白喉、破伤风的目的。
Objective To investigate the levels of anti-pertussis, diphtheria and tetanus in maternal infant in different regions of China. Methods The levels of anti-pertussis, diphtheria and tetanus antibodies in healthy infants at 3 months of age who did not receive DPT (DPT) vaccine were investigated in 8 different regions of China in 10 years respectively. A total of 1 602 anti-pertussis agglutinogens (Aggs), 790 anti-pertussis toxin (PT) and anti-fibrinogen (FHA) antibodies and 1 196 anti-diphtheria and tetanus antibodies were detected. Results The anti-pertussis Aggs and anti-PT, FHA antibodies in infants without DPT were all protected at the level of <1: 320 and <20 EU / ml respectively. The anti-diphtheria and anti-tetanus antibody levels were all <0.01 HAU / ml Level, and this level of low antibody in infants does not change over time, without regard to city or rural areas, developed areas or underdeveloped areas. Conclusions DPT is recommended to the early 2 months of age to promote the use of cell-free DPT in young infants to achieve the goal of preventing pertussis, diphtheria and tetanus effectively.