【摘 要】
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In the 1950s to 1970s, the research on Parkinson\'s disease (PD) and its treatment had mainly been focused on the Nigro-striatal dopamine (DA) neurons as the major site of degeneration in this disease. It contributed to the search for drugs that restore
【机 构】
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Department of Neuroscience,Karolinska Institutet,Biomedicum,Stockholm,Sweden
论文部分内容阅读
In the 1950s to 1970s, the research on Parkinson\'s disease (PD) and its treatment had mainly been focused on the Nigro-striatal dopamine (DA) neurons as the major site of degeneration in this disease. It contributed to the search for drugs that restored DA transmission in this pathway and contributed to the introduction of L-DOPA and DA receptor agonists in its treatment (Borroto-Escuela and Fuxe, 2019).
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