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目的观察耐药肺结核病的临床治疗效果,探讨优化药物治疗方案。方法选择65例复治菌阳具有耐药性的病例,给予对氨基水杨酸异烟肼、利福喷丁、左氧氟沙星、乙胺丁醇、丙硫异烟胺、卷曲霉素方案治疗12个月后,观察痰菌总阴转率、病灶总吸收率、空洞闭合率,随访1年。结果痰菌总阴转率为62.30%,病灶总吸收率为80.33%,空洞均有明显的缩小或闭合,未出现新的空洞,空洞闭合率为39.34%。随访1年无一例复阳,病变尚有一定的吸收。结论治疗方案的痰菌总阴转率、病灶总吸收率、空洞闭合率均较高,有利于耐药肺结核病的治疗。
Objective To observe the clinical effect of drug-resistant pulmonary tuberculosis and to explore the optimal drug treatment plan. Methods Sixty-five cases of drug-resistant Mycobacterium tuberculosis were enrolled in this study. Twelve of them were treated with isoniazid, rifapentine, levofloxacin, ethambutol, prothiocitrin, and capreomycin After month, observe the total negative conversion rate of sputum, the total absorption rate of the lesion, the void closure rate, followed up for 1 year. Results The total negative conversion rate of sputum was 62.30% and the total absorption rate of the lesions was 80.33%. The voids were significantly reduced or closed, no new voids appeared, and the void closure rate was 39.34%. One year follow-up without a case of complex Yang, the lesion still has some absorption. Conclusions The total negative conversion rate of sputum bacteria, the total absorption rate of the lesions and the void closure rate of the treatment are higher, which is in favor of the treatment of drug-resistant pulmonary tuberculosis.